Phosphatidylserine and Testosterone: A Nootropic with Interesting Hormonal Effects

Phosphatidylserine (PS) is a naturally occurring phospolipid that exists in the cell membranes of all species. In simple words, it’s a type of fat that can be found in every cell membrane of the human body that also contains the mineral phosphorus.

Roughly 60 grams of phosphatidylserine can be found in human brain, testes, lungs, muscle tissue, kidneys, liver, and blood plasma. About 50% of the PS in the body exists in neural tissue.

The Functions of PS in the Body Include:
a) Transports molecules in and out of the cell
b) Delivers signals to the interior of the cell membrane
c) Improves signaling between the cells
d) Protects cell membranes from oxidative stress

Because nearly 50% of the phosphatidylserine exists in neural tissue, it’s also believed that the phospholipid has a brain function improving effect. In other words, it’s believed to be a nootropic (smart drug)

…And research supports this belief, as several human studies have found out that phosphatidylserine improves cognitive function, attention, working memory, processing speed, processing accuraccy, and general memory (study, study, study, study)

Not to mention that PS is also known for reducing stress, fatigue, ADHD symptoms, and cognitive decline (study, study, study, study, study, study).

So, phosphatidylserine clearly has some benefits as a brain booster and I guess we can easily call it a well researched nootropic.

However cognitive stuff is not all that this lipid has been researched for:

Phosphatidylserine and Testosterone Levels

why cortigon is the best nootropicThere are two very interesting facts about phosphatidylserine that could make it a potential testosterone booster

…Firstly, it’s a message sender between the cells, which means that it could also improve the signals that come from hormones.

…Secondly, it protects cells (think leydig) from oxidative damage (brains and testicles contain the most of phosphatidylserine in the body).

So in paper, there could be some testosterone boosting effects in phosphatidylserine supplementation due to its ability to act as a secondary message sender and a potential cortisol/oxidative damage blocker.

Fortunately we don’t even have to speculate, as few studies have examined the above already:

Phospatidylserine and Testosterone Research:
a) Few studies have found that phosphatidylserine supplementation lowers cortisol secretion in stressed subjects (study, study), and this study found out that 800 mg’s of daily PS reduced exercise induced rise in cortisol by 30%.

b) This peer-reviewed study from Starks et al. found out that 600 mg’s of daily PS in combination with resistance training produced a staggering 180% improvement in testosterone to cortisol ratio of healthy human subjects when compared to placebo.

phosphatidylserine and cortisol and androgens

At this point, phosphatidylserine becomes a very interesting supplement.

Not only is great for the brain, it seems to also be great for guys who exercise – after all – scientist often use the testosterone to cortisol ratio as a measure to see how effectively the body can build lean muscle mass.

Are there any food sources for phosphatidylserine?

Answer: Bovine brain, chicken heart, pig spleen, pig liver, and certain lechitins (sunflower and soy mainly) are all good sources of PS. However to reach the dosages used in the studies above supplementation is easier, but not required (see a chart of foods highest in PS here).

What are the phosphatidylserine supplements made of?

Answer: Originally PS supplements were all derived from bovine brains, but when the mad cows disease panic started in the US, manufacturers pussied out and started deriving their supplements from plants. That’s why most of the phosphatidylserine on the market is now derived from soy lechitin.

I personally like to use this high quality PS supplement with other nootropics ingredients (affiliate link).


phosphatidylserine (PS) is an interesting lipid, which clearly has some testosterone boosting and cortisol suppressing effects in combination with resistance training.

Not to mention that it’s also a powerful nootropic (brain booster).

With that being said, I don’t supplement with PS myself, as it’s quite expensive and because I already consume plenty of animal organs in my diet to begin with…

…And that’s what you should do too, eat plenty of animal organs, they’re jam-packed with a wide variety of essential nutrients for men’s health, such as the phosphatidylserine 😉

Phosphatidylserine and Testosterone: A Nootropic with Interesting Hormonal Effects was last modified: March 27th, 2017 by Ali Kuoppala

Ali Kuoppala

Ali Kuoppala is the founder of Anabolic Men, and an Independent Researcher that has been credited with organizing the findings that have helped thousands of men reach hormonal balance.


  1. Christopher Walker on 22/04/2015 at 00:35

    I LOVE PS. I take it every single day. About 300mg. Keeps me focused and relaxed.

  2. Elias Fregonezi on 02/03/2016 at 17:27

    you eat raw organs ?

  3. […] Phosphatidylserine is one of natures most powerful anti-depression substances and has actually been shown by the FDA to reverse neurogenerative disease. It’s a naturally occurring compound in human brains, so supplementing with it is very logical. The hormonal benefits of its effects on the hypothalamus and pituitary gland are impressive. […]

  4. […] is one of my all-time favorite daily use supplements, mainly because phosphatidylserine is the core ingredient, which has so many positive benefits for men and women alike. Cortigon […]

  5. […] with Alzheimer’s or other cognitive diseases – which is why it is also included alongside Phosphatidylserine in the powerful natural supplement Cortigon in our Marketplace. The antioxidant-packed gingko […]

  6. Marco on 20/09/2016 at 23:02

    Nice article, Do I need to cycle phosphatidylserine ?

  7. Bryan Ward on 17/06/2017 at 23:59

    You can still get bovine PS in a product called brain beef on Amazon.

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