The Estrogen Flush Protocol: A Three Step Formula For Estrogen Removal

Estrogen as you probably know already, is the principal female hormone in the human body…

…It causes feminizing effects inside the male body and down regulates testosterone production.

In other words: High estrogen often correlates with low testosterone levels.

And while most men think that they don’t have to worry about the female hormone because they’re men, are horribly wrong. That’s because with the modern day diet, sedentary lifestyle, and toxic chemicals, most of the modern day males are walking estrogen powerhouses.

Thus, why few years ago I came up with a protocol that I like to call “The 3 Step Estrogen Flush”. It combines 3 natural compounds in a stack fashion, and their synergistic effect is extremely effective at lowering male estrogen levels.

Without further rambles, let’s take a look at the protocol step-by-step:

Step 1: IC3

estrogen suppressing supplementThe protocol starts with a natural compound called indole-3-carbinol (IC3).

It’s a naturally occurring substance that can be found in cruciferous vegetables such as: broccoli, brussel sprouts, cauliflower, kale, etc.

IC3 can also be taken as a supplement (affiliate link), which provides you with a much stronger dose than the one you could potentially get by eating a bunch of crusiferous vegetables.

But why IC3?

…Firstly, it helps the liver to metabolize estrogen molecules away from the body.

…Secondly, it converts strong estrogen molecules into their less potent forms.

And it comes not as a surprise that in this study, DIM supplementation effectively halved estrogen levels in healthy human subjects.

Step 2: Methylator

choline gets rid of estrogen naturallyThe protocol continues with betaine and/or choline, which are both strong methylators in the human body.

Basically the step 2 means that you’re either eating a ton of beets (which is a source of betaine) or a ton of raw eggs (which is a source of choline)…

…And just like in the step 1, you can also supplement with choline and/or betaine to get a stronger effect.

Before you ask, here’s why the second step involves a methylator:

By design your estrogen molecules are all missing one methyl group, and this means that your liver can’t chelate them out of the body. In other words they’re stuck inside of you…

…And this is where methylators get involved. Because when you consume a methylator (choline or betaine) you introduce those missing methyl groups into the body. The methyl groups will then “complete” the empty spots in the estrogen molecules, which makes it possible for your liver to chelate them out of the body.

And that’s simply why step 2 means that you’re either eating plenty of raw eggs and beets, or supplementing with either choline or betaine.

My recommended supplement would be the well-absorbing and highly bioavailable CDP choline from Jarrow Formulas (affiliate link).

To keep you on the map, here’s what we’ve done so far:

Firstly you took some IC3, which helped your liver to metabolize estrogen and convert it into less potent forms. Then you consumed a methylator which furthermore improved the detoxification of estrogens due to improved chelation.

Step 3: Calcium-D-Glucarate

calcium-d-glucarate lowers estrogenNow that you’ve gotten that estrogen moving out, you need to make sure that it gets out of the body quickly, so that it doesn’t get reabsorbed back to the body through the intestinal walls.

And that’s where the compound number three comes into play…

…It’s a naturally occuring fiber called Calcium-D-Glucarate, which can be found in the jelly portion of the skin of dark berries.

In other words: Step 3 means that you’re either going to eat a bunch of dark berries, or you’re going to supplement with some strong Calcium-D-Glucarate (affiliate link).

But why the Calcium-D-Glucarate?

Calcium-D-Glucarate works by binding into those already exiting estrogen molecules. It makes it easier for the molecules to exit the body, so that they won’t get reabsorbed back into the body via the intestines.

And to put you back on the map again, here’s a quick walkthrough:

You started with DIM which metabolized estrogen and converted it into less potent derivates. Then you continued with a methylator which furthermore improved the estrogen chelation process. And to finish off the protocol you took some Calcium-D-Glucarate which helped your body to completely remove the estrogen molecules via your intestines.


So that was the 3 step estrogen flush protocol. A simple three step formula that can be done with either supplements, or with simple everyday foods.

Since I published this protocol few months ago, I’ve also gotten a lot of questions about the timing. And here’s one example on how you could do the 3 step flush:

Take DIM or eat plenty of crusiferous vegetables – Wait 10 minutes – Take choline and/or betaine or eat plenty of raw eggs and/or beets – Wait 10 minutes – Take some Calcium-D-Glucarate or eat plenty of dark berries to finish of the protocol.

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The Estrogen Flush Protocol: A Three Step Formula For Estrogen Removal was last modified: July 13th, 2017 by Ali Kuoppala

Ali Kuoppala

Ali Kuoppala is the founder of Anabolic Men, and an Independent Researcher that has been credited with organizing the findings that have helped thousands of men reach hormonal balance.
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  1. Steve on 11/01/2014 at 20:34

    What is the time duration? All within the same day? Everyday for a week? Just trying to understand timing and duration. Looking forward to giving it a try!

    • Anabolic Men on 11/01/2014 at 21:07

      Hi Steve! Good question. I usually consume them all inside 1-2 hour window for the best effect. And you can consume them daily, just like regular food.

  2. Nare on 08/06/2014 at 20:50

    I’m currently supplementing with 250mg nettle root extract, 200mg DIM and 5g Macs powder. How long will it take to get rid of the unwanted estrogen from my body?

    • Ali Kuoppala on 15/06/2014 at 14:42

      Well, I can’t say for sure how long it’ll take as every person has different amounts of estrogen, and lifestyle habits can make a huge difference.

      However you should expect your levels to halve in less than 3 months with those.

      • Joshua French on 12/02/2017 at 20:40

        is it ok to take these supplements and still eat anti estrogen foods?

  3. lioness81 on 18/08/2014 at 18:18

    Does this work for women too? Most pre-menopausal women these days are very estrogen dominant

  4. bahadur on 19/08/2014 at 16:26

    What about Turmeric??? doesn’t it lower estrogen in body? you in one your post that it may be even helpful for gynecomastia. Have you tired turmeric??

  5. Luke on 19/08/2014 at 20:51

    What dosage of DIM and Calc should be taken? In the UK all the products have completely different serving sizes.

  6. Patrik Lööf on 19/08/2014 at 21:02

    Great article as always. Just a question – how do you get stuff from Amazon? When I try to order ( living in Sweden) the producs simplay state that they cannot ship outside the USA? 🙁

    • Dave Tamares-Little on 08/07/2016 at 15:59

      Try Amazon UK. you should have better luck

  7. Jimmy on 20/08/2014 at 13:51

    The lower you push estrogen, the harder the hypothalamus and piturity work to produce more LH to stimulate testosterone production which sounds great in theory right?

    However in reality, this is not all good news and according to the testosterone replacement thread on T-Nation, there is a sweet spot with estrogen which is around 1/3rd into the normal range, furthermore according to Dr Crisler (one of the leading US based TRT doctors), the ideal is about 1/2 way into the normal range.

    Just curious Ali, where does your level sit within the reference range? These guys (above) use arimidex and exemestane to achieve these results. Are you able to push oestrogen that low naturally? If not, how low have you gotten your levels using natural means? It might also be worth assessing if your pushing it too low, estrogen has many functions (lipid metabolism, vision, libido etc) in the male body also so if you push it too low, I know from experience that libido goes down the toilet for starters.

    • The McDougal Bugle on 02/11/2015 at 10:36


  8. ANTHONY on 22/08/2014 at 22:17

    I have should I cycle DIM? Or can I take it daily. I am also taking resveratrol, shilajit, spirulina, and cur cumin. Should I cycle these? I also take vitamin D3, and Zinc daily.

  9. bahadur on 06/09/2014 at 15:52

    The DIM suppliments in found in whole foods store has soy on it.. it is in the women section… i am confused… is there any DIM suppliment which doesnt have soy???.. is DIM phytoestrogens???

  10. Matthew Lorenzo on 17/02/2016 at 06:50

    If I try this method will it give me a deeper voice? I’m 24 and people mistake me for a woman on the phone and I’m so tired of it!

  11. Potassium Cyanide on 01/05/2016 at 17:29

    Although not strongly on topic, NAC helps liver flush out bad stuff.
    But it’s also counterindicated that despite increasing glutathione, NAC lowers T unless used with selenium.
    When used with selenium, NAC selenium combo can increase T so much that pituitary lowers the FSH, LH levels.
    And idea ali on how to fix this and maintain high DHT levels while still taking NAC/selenium combo ?

  12. Joshua French on 12/02/2017 at 20:40

    is it ok to take these supplements and still eat anti-estrogen foods?

  13. Sambuddho Chakravarty on 26/02/2017 at 10:59

    Question for you: In my country you can easily get choline + inositol. I read somewhere that inositol reduces testosterone in women … Does it have the same effect in men also ? Can I take it or no ?

  14. Nico on 12/03/2017 at 19:05

    Hey, I’m 17 and have reduced my gyno greatly by simply incorporating a dim supplement. But I want to completely get rid of gyno. Would this combo be effective at completely getting rid of it. Thanks.

  15. Craig on 03/05/2017 at 10:54

    You use Indole-3-carbionol and DIM interchangeably. I see DIM is Di-Indoly Methane, whereas you have Indole-3-carbionol. Are these the same, or should I be taking both? Or just Indole-3-carbionol?

  16. Dani on 25/05/2017 at 06:54

    I am following this protocol combined with Mucuna and a multi-mineral (“only trace minerals” from Life Extension and “Selenium” from Healthy Origins), these minerals are widely recommended by this website for male health. Strongest erections ever from the 1st day!!!! Loving the protocol and sharing it with the world.

  17. newsuperhuman on 25/05/2017 at 21:13

    This guy doesn’t even bother to answer many of the good questions his readers ask him about his protocol, and you’re going to trust him? Good luck.

  18. Rugby.Hunk on 13/06/2017 at 20:17

    i bought all of those products. but what is the daily dosage of each should i take?

  19. Kevin Royce on 01/08/2017 at 14:12

    This looks like a pretty old thread… Hopefully someone is still monitoring it. With above mentioned products, to get the desired effect should we just follow the dosing directions on the bottle? Also, are there better products currently available in 2017?

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