Forskolin and Testosterone: Potent Natural T-Booster and cAMP Activator

Forskolin is a labdane diterpene found in an Indian plant called Coleus Forskohlii. Dozens of studies have proven it to be a potent cAMP activator, while one human study found that forskolin increases testosterone. One study even found that the herb activates androgen receptors.

Forskolin is not that popular of a supplement for sure, and most commonly its used as a fat burner (not that effective IMHO), vasodilator, or to relieve glaucoma symptoms. However there’s one interesting benefit to Forskolin which everyone else seems to miss.

It has shown some very promising effects on male testosterone levels:

Forskolin as a Testosterone Booster

forskolin testosteroneLike I said above, Forskolin as a supplement is not that popular, and it’s use as a testosterone booster is even less popular.

With that being said, there’s still some interesting studies about this fascinating diterpene…

…Firstly, Forskolin is well known to increase the levels of cAMP in cells and tissue (cAMP is a messenger that transports biological signals between cells and hormones). Increased cAMP levels should by all laws of common sense, increase the sensitivity, amount, and activity of hormones all over the body.

…Secondly, in this in vitro study, Forskolin was able to raise testosterone levels by almost 200% in isolated rat leydig cells. Many scientists use Forskolin as a “positive control” in cell studies because it has positive testosterone stimulating effect on testicular leydig cells.

…Thirdly, this study led by a scientist Michael P. Godard, had 30 obese male subjects who were divided into two groups, the Forskolin group and the placebo group.

The Forskolin group received 250 mg’s of 10% Forskolin extract twice a day for 12 weeks, and the placebo group obviously got a fake pill.

At the end of the 12 week period, the Forskolin group noted a 33% increase in testosterone when compared to placebo.

NOTE: The only downfall with Gorard’s study is the fact that it was funded by the company that manufactures a weight loss supplement called forslean, which contains forskolin as one of the active ingredients. However the study has since been peer-reviewed by several other researchers and it has been published in countless of high quality medical journals, meaning that the study should be pretty legit after all.

…Fourthly, in this in-vitro study, the researchers found out that forskolin is a potent activator of androgen receptors in multiple different human cells. This activation was likely due to the fact that forskolin increases cAMP, which then increases protein kinase A (PKA), which is an enzyme that regulates glycocen, sugar, and lipid metabolism inside the receptors. These results suggest that forskolin is not only a testosterone booster, but also a “testosterone utilizer”, as it activates the receptor sites in which testosterone molecules bind into.

Conclusion

There’s some interesting studies suggesting that Forskolin might be a potential testosterone booster, albeit more studies would be needed to validate that claim.

We should also remember that as Forskolin increases cAMP levels in the cells, it might also elevate other hormones, not only testosterone (in theory, you probably shouldn’t use anything that boost cAMP if you’re battling with high estrogen levels).

If you want to try Forskolin, this brand would probably be the best pick (affiliate link).

Forskolin and Testosterone: Potent Natural T-Booster and cAMP Activator was last modified: February 5th, 2017 by Ali Kuoppala
Ali Kuoppala

Ali Kuoppala

Ali Kuoppala is the founder of Anabolic Men, and an Independent Researcher that has been credited with organizing the findings that have helped thousands of men reach hormonal balance.
Ali Kuoppala
  • Lukus Leonard

    How did your Forskolin use go man!!?? I just looked into it, and Mike Matthews from Legion Nutrition uses it in his PHEONIX Fat burning supplement. ??

    • Forskolin was definitely a keeper. I still continue to use it in a stack with L-Carnitine and creatine before and after workouts to activate androgen receptors.

      • Tom

        I’m using l-carnitine:l-tartate(4g), creatine(10g) and mucuna purines powder(10g) at around 7am – all together at the same time – every morning( for convenience). Im just about to hit my first rest period for a week (I’m using a 2 week on, 1 week off protocol for everything). I’m not entirely sure if its done anything or if I’m being super impatient… what did you begin to feel from using the stack/am i using them at the wrong time??
        i also fast from the evening to 11am every morning (skip breakfast) – is my protocol going to break my fast?

        • Should be all good mate.

          • Pécheur

            Hey Ali I wanted to ask you,

            Do you recommend doing both weight training and HIIT? Or should I choose one?

  • The McDougal Bugle

    what r some of ur stats mate? deadliest, bench

    • Robin ThickeVEVO

      In one article,he mentioned his following stats
      deadlift -220kg
      bench press 127kg

  • Donsods

    Ali–great post. Have you ever thought of occasionally during a mail-bag type post where you answer reader questions? With your vast knowledge and rich archives, I’d imagine you could replace an article once or twice a month at least.

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  • Robin ThickeVEVO

    You told that saturated fats aren’t bad but the doctors call it as a harmful fat which causes heart disease.I’m confused about this topic.May be there is an upper limit of saturated fat intake or vigorous exercises stimulate the conversion of SFAs into testosterone.Please Ali!! Try to explain this topic briefly.

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